Trimeprimina [Italian]

Trimeprimina [Italian] Brand names, Trimeprimina [Italian] Analogs

Trimeprimina [Italian] Brand Names Mixture

No information avaliable

Trimeprimina [Italian] Chemical_Formula

C₂₀H₂₆N₂

Trimeprimina [Italian] RX_link

http://www.rxlist.com/cgi/generic2/trimipramine.htm

Trimeprimina [Italian] fda sheet

Trimeprimina_[Italian] FDA

Trimeprimina [Italian] msds (material safety sheet)

Trimeprimina [Italian] Synthesis Reference

No information avaliable

Trimeprimina [Italian] Molecular Weight

294.434 g/mol

Trimeprimina [Italian] Melting Point

45 ^oC

Trimeprimina [Italian] H₂O Solubility

Slightly soluble

Trimeprimina [Italian] State

Solid

Trimeprimina [Italian] LogP

4.453

Trimeprimina [Italian] Dosage Forms

Capsule; Tablet

Trimeprimina [Italian] Indication

For the treatment of depression and depression accompanied by anxiety, agitation or sleep disturbance

Trimeprimina [Italian] Pharmacology

Trimipramine is a tricyclic antidepressant. It was thought that tricylic antidepressants work by inhibiting the re-uptake of the neurotransmitters norepinephrine and serotonin by nerve cells. However, this response occurs immediately, yet mood does not lift for around two weeks. It is now thought that changes occur in receptor sensitivity in the cerebral cortex and hippocampus. The hippocampus is part of the limbic system, a part of the brain involved in emotions. Presynaptic receptors are affected: a1 and b1 receptors are sensitized, a2 receptors are desensitised (leading to increased noradrenaline production). Tricyclics are also known as effective analgesics for different types of pain, especially neuropathic or neuralgic pain. A precise mechanism for their analgesic action is unknown, but it is thought that they modulate anti-pain opioid systems in the CNS via an indirect serotonergic route. They are also effective in migraine prophylaxis, but not in abortion of acute migraine attack. The mechanism of their anti-migraine action is also thought to be serotonergic.

Trimeprimina [Italian] Absorption

Rapid absorption

Trimeprimina [Italian] side effects and Toxicity

Side effects include agitation, coma, confusion, convulsions, dilated pupils, disturbed concentration, drowsiness, hallucinations, high fever, irregular heart rate, low body temperature, muscle rigidity, overactive reflexes, severely low blood pressure, stupor, vomiting

Trimeprimina [Italian] Patient Information

PATIENT INFORMATION

Follow the links

http://www.rxlist.com/cgi/generic2/trimipramine_pi.htm

http://www.rxlist.com/cgi/generic2/trimipramine_wcp.htm

http://www.drugs.com/cons/Trimipramine.html

Trimeprimina [Italian] Organisms Affected

Humans and other mammals